Esketamine, also known by the brand name Spravato®, is a promising new antidepressant that has the potential to work very quickly. Esketamine is chemically related to ketamine and is administered as a nasal spray. Unlike previous antidepressants, many patients feel better after the first or second treatment. Esketamine works in 50-70% of patients with treatment-resistant depression.

Why Choose Esketamine?
Esketamine is the first FDA-approved therapy found to work for treatment-resistant depression with almost immediate effect. It also may reduce suicidal thoughts and feelings.
What can I expect with Esketamine?
Most oral antidepressants work by increasing levels of neurotransmitters (serotonin, norepinephrine and dopamine) in areas of the brain that affect mood. Esketamine is a nasal spray that is self-administered under the supervision of our doctors and staff. We believe that esketamine works on a different chemical system (glutamate) to create new, stronger connections.
Side Effects
Most side effects occur during the two hours patients are being observed. These may include:
- Dissociation (feeling disconnected from yourself, your thoughts, feelings, space and time)
- Dizziness
- Nausea
- Feeling sluggish or tired
- Spinning sensation
- Reduced sense of touch and sensation
- Anxiety
- Lack of energy
- Increased blood pressure
- Vomiting
- Feeling drunk or euphoric
Most patients have no side effects during the time between treatments.
More Information About Esketamine
- Esketamine is administered two times per week for four weeks and, if effective, is then administered every one to two weeks afterward.
- Ongoing maintenance treatments seem to be necessary to prevent relapse.
- Per FDA regulations, patients taking esketamine self-administer the medication in a physician’s office and must be monitored in the office for 2 hours.
- Patients cannot drive for the rest of the day after treatments but may drive again the next morning.
- Some patients may experience nausea or vomiting. Because of this, patients should avoid eating two hours before, and drinking liquids 30 minutes before, treatment.
TMS TREATMENT
KETAMINE TREATMENTS
KETAMINE TREATMENTS
Now providing esketamine, IV ketamine, and ketamine assisted psychotherapy.
ECT TREATMENT
CLINICAL TRIALS
ADDITIONAL THERAPIES
TMS TREATMENT
ECT TREATMENT
KETAMINE TREATMENTS
KETAMINE TREATMENTS
Now providing esketamine, IV ketamine, and ketamine assisted psychotherapy.
CLINICAL TRIALS